FRONTLINE - Kills flees and ticks fast... and it lasts.

Our research data shows FRONTLINE Brand Products will kill fleas within 12 hours of contact with your treated pet^**. Ticks will die within 48 hours of contact with your treated pet².

FRONTLINE Top Spot and Plus spread over the pet's body by a process called translocation. When applied, these products are gradually dispersed by the pet's natural oils, collecting in the oil glands in the skin. It is then "wicked" onto the hair over the next 30 days. The translocation process can take up to 24 hours to complete.

Fleas and ticks do not have to bite your pet for FRONTLINE Brand Products to work. FRONTLINE Brand Products kill fleas and ticks if they simply come into contact with your pet's haircoat. The fleas will die within 12 hours of contact with your treated pet^**, and ticks will die within 48 hours².

After the application of a FRONTLINE Brand Product, you may see more fleas, but this is an indication that the FRONTLINE Brand Product is working. FRONTLINE Brand Products make fleas hyperexcited, drawing them to the top of the haircoat before dying. This will make them more visible to you.

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Brand Products. Consecutive monthly applications of a FRONTLINE Brand Product to your pet will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Once new adult fleas jump on your pet, they must be present on the host for at least 24 to 36 hours before they can lay eggs. Our research data indicates that FRONTLINE Brand Products, when used monthly, will kill your pet's fleas within 12 hours of application^** - before they can lay eggs.

FRONTLINE Brand Products do not carry an expiration date. We recommend storing FRONTLINE Brand Products at room temperature and keeping them sealed in their original packaging. If stored under these conditions, FRONTINE Brand Products will not expire.

FRONTLINE Brand Products remain effective for 30 days, even if a pet swims or is bathed. After application, keep the dog or cat from getting wet until the application area appears dry, usually 24 hours. If a FRONTLINE Brand Product is to be applied after a bath, make sure the pet is completely dry before application.

FRONTLINE Brand Products are not systemically active and have no known adverse interactions with systemic medications.

There are no known interactions between FRONTLINE Brand Products and any other flea- and tick-control products. However, it is recommended to wait at least 24 hours between applications.

Effective May 2003, FRONTLINE Plus and FRONTLINE Top Spot were approved by the Environmental Protection Agency (EPA) to be used on pregnant, lactating and breeding dogs and cats. FRONTLINE Spray is not approved to be used on pregnant, lactating and breeding dogs and cats. In addition, FRONTLINE Plus small size that was initially labeled for 11-22 lb dogs has now been approved for the use on any size dog up to 22 lbs.

FRONTLINE Brand Products are now approved for the rapid elimination of chewing lice infestations on dogs and cats and as an aid in control of sarcoptic mange infestations on dogs.

Also, any FRONTLINE Brand Product may be applied to dogs and cats as young as 8 weeks of age and older.

FRONTLINE Brand Products are available in three formulations to make it easy for you to provide your pet with the flea and tick control that is best for them. FRONTLINE Plus is a convenient once-a-month topical product offering long-lasting, complete control for adult fleas, flea eggs and larvae, and all four major species of ticks. FRONTLINE Top Spot and FRONTLINE Plus provide fast-acting, long-lasting flea and tick control for dogs and cats. FRONTLINE Spray offers quick elimination of existing flea and tick infestations. Ask your veterinarian which FRONTLINE Brand Product is the best choice for your pet.

No. FRONTLINE Brand Products are intended for use on dogs and cats only. It is not recommended for use on other species.

Research results show that FRONTLINE Brand Products control fleas and ticks for a full month, so reapplication is unnecessary within 30 days.

FRONTLINE Brand Products for dogs and cats are available from your family veterinarian.

Individual sensitivities, while rare, may occur after using any pesticide product. Since FRONTLINE Brand Products are topical some pets may experience temporary irritation at the site of product application. If signs persist, or become more severe within a few days of application, consult your veterinarian immediately.

It is Merial's sales policy to sell our small animal products only where a veterinarian/client/patient relationship exists. Merial believes that the veterinarian is the only professional qualified to serve the health care needs of pets, the concerns of their owners and the appropriate use of our small animal products such as FRONTLINE Brand Products.

All FRONTLINE Brand Products may be applied to dogs and cats as young as 8 weeks of age.